Afatinib versus methotrexate in older patients with second-line recurrent and/or metastatic head and neck squamous cell carcinoma: subgroup analysis of the LUX-Head
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چکیده
Citation Clement, P. M., T. Gauler, J. P. Machiels, R. I. Haddad, J. Fayette, L. F. Licitra, M. Tahara, et al. 2016. “Afatinib versus methotrexate in older patients with second-line recurrent and/or metastatic head and neck squamous cell carcinoma: subgroup analysis of the LUXHead & Neck 1 trial†.” Annals of Oncology 27 (8): 1585-1593. doi:10.1093/annonc/mdw151. http://dx.doi.org/10.1093/annonc/mdw151.
منابع مشابه
Afatinib versus methotrexate in older patients with second-line recurrent and/or metastatic head and neck squamous cell carcinoma: subgroup analysis of the LUX-Head & Neck 1 trial†
BACKGROUND In the phase III LUX-Head & Neck 1 (LHN1) trial, afatinib significantly improved progression-free survival (PFS) versus methotrexate in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) patients progressing on/after platinum-based therapy. This report evaluates afatinib efficacy and safety in prespecified subgroups of patients aged ≥65 and <65 years. P...
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